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In this work, for the prediction of protein lipid modification sites, we developed an update version of GPS algorithm, which adopted the ALC-PSO strategy as shown in Fig.
GPS-Lipid was proven to be evidently superior to other similar tools.
Due to their essential physiological functions, the dysfunctions of lipid modification may lead to many sorts of diseases.
For example, the overexpression of palmitoyl acyltransferases (PATs) may implicate in schizophrenia.
Although the enzymatic processes of protein lipidation vary greatly, different types of lipid groups are still found to modify similar protein substrates, which implies a strong co-regulation between different lipid modifications.
One of the most striking example is the regulation of small GTPases in subcellular trafficking by prenylation and palmitoylation.
From the published literatures, we manually collected 737 S-palmitoylation sites in 361 proteins, 106 S-farnesylation sites in 97 proteins, 95 S- geranylgeranylation sites in 70 proteins and 283 N-myristoylation sites in 281 proteins.